Current understanding of prostate cancer biomarkers

被引:0
|
作者
Popov, S. V. [1 ,2 ]
Guseynov, R. G. [1 ,2 ,3 ]
Vasin, A. V. [4 ]
Sivak, K. V. [1 ,5 ]
Pomeshkin, E. V. [1 ]
Perepelitsa, V. V. [1 ,2 ]
Bunenkov, N. S. [1 ,6 ,7 ]
Lelyavina, T. A. [7 ]
机构
[1] St Lukas Clin Hosp, 46 Chugunnaya St, St Petersburg 194044, Russia
[2] St Petersburg Med & Social Inst Let, 72 Kondratievskiy Prospekt, St Petersburg 195271, Russia
[3] St Petersburg State Univ, 7-9 Univ Skaya Naerezhnaya, St Petersburg 199034, Russia
[4] Peter Great St Petersburg Polytechn Univ, Inst Biomed Syst & Biotechnol, 29 Polytech Skaya, St Petersburg 195251, Russia
[5] AA Smorodintsev Res Inst Influenza, 15-17 Prof Popova St, St Petersburg 197022, Russia
[6] IP Pavlov First St Petersburg State Med Univ, 6-8 Lva Tolstogo St, St Petersburg 197022, Russia
[7] VA Almazov Natl Med Res Ctr, 2 Akkuratova St, St Petersburg 197341, Russia
来源
ONKOUROLOGIYA | 2023年 / 19卷 / 04期
关键词
prostate cancer; biomarker; prostate biopsy; diagnostics; prognosis; HEALTH INDEX PHI; DIAGNOSTIC PERFORMANCE; GENOMIC CLASSIFIER; BIOPSY; VALIDATION; PREDICTOR; 4KSCORE; MEN;
D O I
10.17650/1726-9776-2023-19-4-148-157
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Worldwide, prostate cancer has remained one of the most common malignant neoplasms among men and it is accompanied by high mortality rates. Standard methods for diagnosing prostate cancer have limited sensitivity and specificity, unnecessary biopsies are often performed, and the risk of overdiagnosis of the disease and overtreatment of patients is high. The review considers diagnostic and prognostic biological markers of prostate cancer proposed in recent years. Theoretical foundations for the use of new biomarkers are analyzed. The characteristics and practical significance of biomarkers of various groups (immunohistochemical, molecular and genetic, prostate specific antigen-associated, volatile organic metabolites) are presented. The need for further large-scale scientific research in the field of biomarker application in prostate cancer, criteria for their selection and evaluation are described. The introduction of modern diagnostic and prognostic markers into real clinical practice opens up new opportunities for improvement of prostate cancer diagnosis, individual prognosis, and rationalization of treatment strategy.
引用
收藏
页码:148 / 157
页数:10
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