biomarkers;
prostate cancer;
HEALTH INDEX PHI;
ANTIGEN VELOCITY;
ACTIVE SURVEILLANCE;
KALLIKREIN MARKERS;
SERUM SARCOSINE;
BIOPSY RECLASSIFICATION;
RADICAL PROSTATECTOMY;
PROGNOSTIC VALUE;
PRECURSOR FORM;
RISK;
D O I:
10.2217/fon.15.318
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Biomarkers can improve prostate cancer diagnosis and treatment. Accuracy of prostate-specific antigen (PSA) for early diagnosis of prostate cancer is not satisfactory, as it is an organ-but not cancer-specific biomarker, and it can be improved by using models that incorporate PSA along with other test results, such as prostate cancer antigen 3, the molecular forms of PSA (proPSA, benign PSA and intact PSA), as well as kallikreins. Recent reports suggest that new tools may be provided by metabolomic studies as shown by preliminary data on sarcosine. Additional molecular biomarkers have been identified by the use of genomics, proteomics and metabolomics. We review the most relevant biomarkers for early diagnosis and management of localized prostate cancer.
机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USAUniv Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USA
Leapman, Michael S.
Nguyen, Hao G.
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机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USAUniv Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USA
Nguyen, Hao G.
Cooperberg, Matthew R.
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机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Epidemiol & Biostat, San Francisco, CA 94143 USAUniv Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94143 USA
机构:
Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USAMed Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
Hall, William A.
Lawton, Colleen A.
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机构:
Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USAMed Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
Lawton, Colleen A.
Jani, Ashesh B.
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h-index: 0
机构:
Emory Univ, Dept Radiat Oncol, Atlanta, GA 30322 USAMed Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
Jani, Ashesh B.
Pollack, Alan
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机构:
Univ Miami, Dept Radiat Oncol, Coral Gables, FL 33124 USAMed Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
Pollack, Alan
Feng, Felix Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USAMed Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA