Palladium-Catalyzed [5+4] Cycloaddition of 4-Vinyl-4-Butyrolactones with N-Tosyl Azadienes: Construction of Nine-Membered Ring

被引：5

作者：

Wang, Lan ^{[1
]}

Yang, Sen ^{[1
]}

Tang, Yi ^{[1
]}

Li, Kuan ^{[1
]}

Lu, Mengxi ^{[1
]}

Guo, Hongchao ^{[1
]}

机构：

[1] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; VINYLETHYLENE CARBONATES; BENZOFURAN DERIVATIVES; HETEROCYCLES; ANNULATION; ACCESS; REARRANGEMENT; IMINES;

D O I：

10.1021/acs.joc.4c00245

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we reported the palladium-catalyzed formal [5 + 4] cycloaddition reactions between 4-vinyl-4-butyrolactones (VBLs) and azadienes. Under mild reaction conditions, a wide range of benzofuran-fused 9-membered heterocyclic compounds had been provided in moderate to excellent yields with exclusive regioselectivities and excellent diastereoselectivities. The practical applicability of the synthesis was demonstrated through scale-up reaction and further transformation.

引用

页码：5019 / 5028

页数：10

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