Palladium-Catalyzed [5+4] Cycloaddition of 4-Vinyl-4-Butyrolactones with N-Tosyl Azadienes: Construction of Nine-Membered Ring

被引：5
|
作者：
Wang, Lan [1 ]
Yang, Sen [1 ]
Tang, Yi [1 ]
Li, Kuan [1 ]
Lu, Mengxi [1 ]
Guo, Hongchao [1 ]
机构：
[1] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE SYNTHESIS; VINYLETHYLENE CARBONATES; BENZOFURAN DERIVATIVES; HETEROCYCLES; ANNULATION; ACCESS; REARRANGEMENT; IMINES;
D O I：
10.1021/acs.joc.4c00245
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, we reported the palladium-catalyzed formal [5 + 4] cycloaddition reactions between 4-vinyl-4-butyrolactones (VBLs) and azadienes. Under mild reaction conditions, a wide range of benzofuran-fused 9-membered heterocyclic compounds had been provided in moderate to excellent yields with exclusive regioselectivities and excellent diastereoselectivities. The practical applicability of the synthesis was demonstrated through scale-up reaction and further transformation.
引用
收藏
页码：5019 / 5028
页数：10
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