Biomechanical comparison of two different compression screws for the treatment of odontoid fractures in human dens axis specimen.

Background: Lag screw osteosynthesis for odontoid fractures has a high rate of pseudoarthrosis, especially in elderly patients. Besides biomechanical properties of the different screw types, insufficient fragment compression or unnoticed screw stripping may be the main causing factors for this adverse event. The aim of the study was to compare two screws in clinical use with different design principles in terms of compression force and stability against screw stripping. Methods: Twelve human cadaveric C2 vertebral bodies were considered. Bone density was determined. The specimens were matched according to bone density and randomly assigned to two experimental groups. An odontoid fracture was induced, which were fixed either with a 3.5 mm standard compression screw or with a 5 mm sleeve nut screw. Both screws are certified for the treatment of odontoid fractures. The bone samples were fixed in a measuring device. The screwdriver was driven mechanically. The tests were analyzed for peak interfragmentary compression and screw-in torque with a frequency of 20 HzFindings: The maximum fragment compression was significantly higher with screw with sleeve nut at 346.13(SD +/- 72.35) N compared with classic compression screw at 162.68(SD +/- 114.13) N (p = 0.025). Screw stripping occurred significantly earlier in classic compression screw at 255.5(SD +/- 192.0)degrees rotation after reaching maximum compression than in screw with sleeve nut at 1005.2(SD +/- 341.1)degrees (p = 0.0039). Interpretation: Screw with sleeve nut achieves greater fragment compression and is more robust to screw stripping compared to classic compression screw. Whether the better biomechanical properties lead to a reduction of pseudoarthrosis has to be proven in clinical studies.