Oxidative Amination of Aldehydes with Amines into α-Amino Ketones

被引：3
|
作者：
Tian, Jie-Sheng [1 ]
Xu, Shuang-Wen [1 ]
Bi, Yan-Hang [1 ]
Cao, Zhan-Zhi [1 ]
Loh, Teck-Peng [2 ,3 ]
机构：
[1] Northwestern Polytech Univ, Sch Chem & Chem Engn, Xian 710072, Peoples R China
[2] Henan Univ Technol, Coll Adv Interdisciplinary Sci & Technol, Zhengzhou 450001, Peoples R China
[3] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol CCEB, Singapore 637371, Singapore
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 49期
关键词：
C BOND-CLEAVAGE; SECONDARY; DOPAMINE;
D O I：
10.1021/acs.orglett.3c03771
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oxidative amination for the installation of nitrogen functional molecules from nitrogen nucleophiles has always been a very challenging topic in organic synthesis. Here we report a novel conversion of different aldehydes with secondary amines for the synthesis of diversified alpha-amino ketones. This method can be achieved through oxidative rearrangement of an in situ-generated enamine intermediate promoted by commercially available sodium percarbonate. Furthermore, this one-pot process is also suitable for the functional modification of complex molecules.
引用
收藏
页码：8922 / 8926
页数：5
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