Oxidative Amination of Aldehydes with Amines into α-Amino Ketones

被引：3
|
作者：
Tian, Jie-Sheng [1 ]
Xu, Shuang-Wen [1 ]
Bi, Yan-Hang [1 ]
Cao, Zhan-Zhi [1 ]
Loh, Teck-Peng [2 ,3 ]
机构：
[1] Northwestern Polytech Univ, Sch Chem & Chem Engn, Xian 710072, Peoples R China
[2] Henan Univ Technol, Coll Adv Interdisciplinary Sci & Technol, Zhengzhou 450001, Peoples R China
[3] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol CCEB, Singapore 637371, Singapore
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 49期
关键词：
C BOND-CLEAVAGE; SECONDARY; DOPAMINE;
D O I：
10.1021/acs.orglett.3c03771
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oxidative amination for the installation of nitrogen functional molecules from nitrogen nucleophiles has always been a very challenging topic in organic synthesis. Here we report a novel conversion of different aldehydes with secondary amines for the synthesis of diversified alpha-amino ketones. This method can be achieved through oxidative rearrangement of an in situ-generated enamine intermediate promoted by commercially available sodium percarbonate. Furthermore, this one-pot process is also suitable for the functional modification of complex molecules.
引用
收藏
页码：8922 / 8926
页数：5
相关论文
共 50 条
  • [21] Reductive amination of aromatic aldehydes and ketones with nickel boride
    Regional Research Laboratory, Jorhat 785006, Assam, India
    Journal of the Chemical Society, Perkin Transactions 1, 2000, (04): : 503 - 504
  • [22] Electrocatalytic Reductive Amination of Aldehydes and Ketones with Aqueous Nitrite
    Rooney, Conor L.
    Sun, Qi
    Shang, Bo
    Wang, Hailiang
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 147 (11) : 9378 - 9385
  • [23] Selective primary amination of alcohols, aldehydes and ketones with ammonia
    Yang, Jian
    Yao, Chong
    Luo, Jie
    Shan, Jinjin
    Liu, Jie
    Lu, Chunshan
    Feng, Feng
    Zhang, Qunfeng
    Wang, Qingtao
    Li, Xiaonian
    MOLECULAR CATALYSIS, 2024, 563
  • [24] General Reductive Amination of Aldehydes and Ketones with Amines and Nitroaromatics under H2 by Recyclable Iridium Catalysts
    Sui, Dejun
    Mao, Fei
    Fan, Haipeng
    Qi, Zhengliang
    Huang, Jun
    CHINESE JOURNAL OF CHEMISTRY, 2017, 35 (09) : 1371 - 1377
  • [25] The Synthesis of Amides through Direct Amination of Aldehydes with Amines
    Ma, Yaorui
    Luo, Junfei
    CURRENT ORGANIC CHEMISTRY, 2019, 23 (08) : 901 - 919
  • [26] Direct reductive amination of ketones with amines by reductive aminases
    Li, Bo-Bo
    Zhang, Jing
    Chen, Fei-Fei
    Chen, Qi
    Xu, Jian-He
    Zheng, Gao-Wei
    GREEN SYNTHESIS AND CATALYSIS, 2021, 2 (04): : 345 - 349
  • [27] Electrochemically Oxidative Phosphating of Aldehydes and Ketones
    Ma, Youcai
    Zhang, Xiaohui
    Ma, Chenglong
    Xia, Wen
    Hu, Liangzhen
    Dong, Xiaoyu
    Xiong, Yan
    JOURNAL OF ORGANIC CHEMISTRY, 2023, 88 (07): : 4264 - 4272
  • [28] Solid phase reductive amination reactions with aldehydes and ketones.
    White, B
    DiCesare, JC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U391 - U391
  • [29] Reductive amination of aldehydes and ketones with 2-(tributylamino)ethoxyborohydride
    Mohanazadeh, Farajollah
    Forozani, Mehdi
    Taheri, Azarn
    MONATSHEFTE FUR CHEMIE, 2007, 138 (11): : 1187 - 1189
  • [30] Reductive Amination of Aldehydes and Ketones with 2-(Tributylamino)-ethoxyborohydride
    Farajollah Mohanazadeh
    Mehdi Forozani
    Azam Taheri
    Monatshefte für Chemie - Chemical Monthly, 2007, 138 : 1187 - 1189
12345