The role of TLR4-mediated MyD88/TRAF6/NF-KB signaling and pIgR intestinal expression in chicks during Salmonella enteritidis infection

被引：4
|
作者：
Zhang, C. [1 ]
Ding, Y. [1 ]
Liu, Y. F. [1 ,2 ]
Wang, H. B. [1 ,2 ]
Wang, X. J. [1 ]
Wang, S. Y. [1 ]
Sun, Z. Y. [3 ]
Li, D. J. [1 ,2 ]
机构：
[1] Northeast Agr Univ, Dept Vet Med, Harbin 150030, Peoples R China
[2] Key Lab Prov Educ Dept Heilongjiang Common Anim Di, Beijing, Peoples R China
[3] Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou 510225, Peoples R China
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2023年 / 258卷
关键词：
TLR4; signaling; pIgR; chick; Salmonellaenteritidis; TOLL-LIKE RECEPTORS; POLYMERIC IMMUNOGLOBULIN RECEPTOR; TLR4; LIPOPOLYSACCHARIDE; RNA;
D O I：
10.1016/j.vetimm.2023.110563
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To observe the effect of Salmonella enteritidis (SE)-induced inflammation on pIgR expression in jejunum and ileum. Salmonella enteritidis was orally administered to 7-day old Hyline chicks, which were killed after 1d,3d,7d and 14d. The mRNA expression of TLR4,MyD88,TRAF6,NF-KB, and pIgR was detected by real-time RT-PCR, and pIgR protein was detected by Western blotting. The TLR4 signaling pathway was activated, the mRNA expression of the pIgR in jejunum and ileum was increased, and pIgR protein in jejunum and ileum was up-regulated by SE. In SE-treated chicks,the pIgR in jejunum and ileum was up-regulated on mRNA,and protein level,associated with activation of the TRL4-mediated MyD88/TRAF6/NF-KB signaling pathway, which identifies this as a novel pIgR-related pathway to TLR4 activation.
引用
收藏
页数：6
相关论文
共 40 条
  • [31] ROLE OF MYD88, NOD1 AND NOD2 ON P38 MAPK AND NF-KB ACTIVATION AND RANKL/OPG EXPRESSION INDUCED BY TLR AND IL-1R SIGNALING IN BONE MARROW STROMAL CELLS
    Leite, F. R. M.
    Guimaraes, M. R.
    Cirelli, J. A.
    Zamboni, D. S.
    da Silva, J. S.
    Rossa Junior, C.
    INFLAMMATION RESEARCH, 2011, 60 : 131 - 131
  • [32] A Novel Polysaccharide Isolated From Fresh Longan (Dimocarpus longan Lour.) Activates Macrophage via TLR2/4-Mediated PI3/AKT and MyD88/TRAF6 Pathways
    Lan, Haibo
    Li, Wu
    Xu, Jucai
    Yang, Yuzhe
    Tan, Zhaolun
    Yang, Ruili
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [33] A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways
    Zhong, Jing
    Qiu, Xian
    Yu, Qian
    Chen, Haiyun
    Yan, Chunyan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 163 : 464 - 475
  • [34] THE SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR DAPAGLIFLOZIN EXERTS CARDIOPROTECTIVE EFFECTS AGAINST DOXORUBICIN AND TRASTUZUMAB TOXICITY THROUGH TLR4/MYD88/NF-KB SIGNALING AND NLRP3 INFLAMMASOME PATHWAY
    Maurea, Nicola
    Quagliariello, Vincenzo
    Iaffaioli, Rosario Vincenzo
    De laurentiis, Michelino
    Botti, Gerardo
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (11) : 1192 - 1192
  • [35] The SGLT2 inhibitor dapagliflozin enhanced anticancer activities and exerts cardioprotective effects against doxorubicin and trastuzumab toxicity through TLR4, MyD88, NF-kB signaling and NLRP3 inflammasome pathway
    Maurea, N.
    Quagliariello, V.
    Bonelli, A.
    Caronna, A.
    Grimaldi, I.
    Lombari, C.
    Conforti, G.
    Botti, G.
    ANNALS OF ONCOLOGY, 2020, 31 : S1106 - S1106
  • [36] RETRACTED: Role of ESAT-6 in renal injury by regulating microRNA-155 expression via TLR4/MyD88 signaling pathway in mice with Mycobacterium tuberculosis infection (Retracted Article)
    Zhou, Zhong-Qi
    Wang, Zhi-Kui
    Zhang, Lei
    Ren, Yue-Qin
    Ma, Zhong-Wei
    Zhao, Nan
    Sun, Fu-Yun
    BIOSCIENCE REPORTS, 2017, 37
  • [37] GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney Transplantation
    Su, Shuai
    Zhang, Peng
    Zhang, Qilin
    Yin, Zhikang
    INFLAMMATION, 2019, 42 (06) : 2105 - 2118
  • [38] GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney Transplantation
    Shuai Su
    Peng Zhang
    Qilin Zhang
    Zhikang Yin
    Inflammation, 2019, 42 : 2105 - 2118
  • [39] CORM-2 prevents human gingival fibroblasts from lipoteichoic acid-induced VCAM-1 and ICAM-1 expression by inhibiting TLR2/MyD88/ TRAF6/PI3K/Akt/ROS/NF-?B signaling pathway
    Cheng, Ching-Yi
    Chen, Yu-Hsu
    Vo, Thi Thuy Tien
    Hong, Ying Chui
    Wang, Ching-Shuen
    Vo, Quang Canh
    Chou, Han-Chin
    Huang, Ting-Wei
    Lee, I-Ta
    BIOCHEMICAL PHARMACOLOGY, 2022, 201
  • [40] RETRACTION: Role of EAST-6 in renal injury by regulating microRNA-155 expression via TLR4/MyD88 signaling pathway in mice with Mycobacterium tuberculosis infection (vol 37, BSR20170021, 2017) (Retraction of Vol 37, art no BSR20170021, 2017)
    不详
    BIOSCIENCE REPORTS, 2020, 40
1234