The SGLT2 inhibitor dapagliflozin enhanced anticancer activities and exerts cardioprotective effects against doxorubicin and trastuzumab toxicity through TLR4, MyD88, NF-kB signaling and NLRP3 inflammasome pathway

被引：4
|
作者：
Maurea, N. [1 ]
Quagliariello, V. [2 ]
Bonelli, A. [2 ]
Caronna, A. [2 ]
Grimaldi, I. [2 ]
Lombari, C. [2 ]
Conforti, G. [2 ]
Botti, G. [3 ]
机构：
[1] Ist Nazl Tumori IRCCS Fdn Pascale, Cardiol, Naples, Italy
[2] Ist Nazl Tumori IRCCS Fdn G Pascale, Div Cardiol, Naples, Italy
[3] Ist Nazl Tumori IRCCS Fdn G Pascale, Sci Direct, Naples, Italy
来源：
ANNALS OF ONCOLOGY | 2020年 / 31卷
关键词：
D O I：
10.1016/j.annonc.2020.08.1361
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1969P
引用
收藏
页码：S1106 / S1106
页数：1
相关论文
共 50 条
  • [1] The SGLT2 inhibitor dapagliflozin exerts cardioprotective effects against doxorubicin and trastuzumab toxicity through TLR4, MyD88, NF-kB signaling and NLRP3 inflammasome pathway
    Quagliariello, V. Vincenzo
    De laurentiis, M.
    Bonelli, A.
    Caronna, A.
    Lombari, C.
    Conforti, G.
    Botti, G.
    Maurea, N.
    EUROPEAN JOURNAL OF HEART FAILURE, 2020, 22 : 145 - 145
  • [2] THE SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR DAPAGLIFLOZIN EXERTS CARDIOPROTECTIVE EFFECTS AGAINST DOXORUBICIN AND TRASTUZUMAB TOXICITY THROUGH TLR4/MYD88/NF-KB SIGNALING AND NLRP3 INFLAMMASOME PATHWAY
    Maurea, Nicola
    Quagliariello, Vincenzo
    Iaffaioli, Rosario Vincenzo
    De laurentiis, Michelino
    Botti, Gerardo
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (11) : 1192 - 1192
  • [3] Dapagliflozin, an Sglt2 Inhibitor, Reduces Expression of Myd88, Nlrp3 and Nf-kb During Exposure to Doxorubicin and Trastuzumab in Cellular Models
    Maurea, Nicola
    Paccone, Andrea
    Iovine, Martina
    Buccolo, Simona
    Cerrone, Francesca
    Quagliariello, Vincenzo
    CIRCULATION, 2021, 144
  • [4] The SGLT-2 inhibitor dapagliflozin enhanced anticancer activities and exerts cardioprotective effects against ipilimumab-induced toxicity through MYD88 and NLRP2-mediated pathways
    Quagliariello, Vincenzo
    Bonelli, Annamaria
    Caronna, Antonietta
    Lombari, Maria Cristina
    Conforti, Gabriele
    Buccolo, Simona
    Iovine, Martina
    Botti, Gerardo
    Maurea, Nicola
    EUROPEAN HEART JOURNAL SUPPLEMENTS, 2020, 22 (0N) : N22 - N23
  • [5] The combination therapy of pembrolizumab and trastuzumab exerts cardiotoxic and pro-fibrotic properties in preclinical models: the role of TLR4/MyD88/NF-kB signaling and NLRP3 pathway
    Quagliariello, V. Vincenzo
    Ascierto, P. A.
    Bonelli, A.
    Caronna, A.
    Lombari, C.
    Conforti, G.
    Botti, G.
    Maurea, N.
    EUROPEAN JOURNAL OF HEART FAILURE, 2020, 22 : 146 - 146
  • [6] Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells
    Liu, Xuting
    Lu, Bin
    Fu, Juanli
    Zhu, Xiaokang
    Song, Erqun
    Song, Yang
    JOURNAL OF HAZARDOUS MATERIALS, 2021, 404
  • [7] Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury
    Su, Qiang
    Li, Lang
    Sun, Yuhan
    Yang, Huafeng
    Ye, Ziliang
    Zhao, Jinmin
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 47 (04) : 1497 - 1508
  • [8] SGLT2 i Dapagliflozin reduces NF-kB expression in heart and kydneys of preclinical models exposed to doxorubicin through MYd-88 and NLRP3 pathways: an hystological study
    Maurea, N.
    Bisceglia, I.
    Iovine, M.
    Paccone, A.
    Florio, F.
    Grimaldi, S.
    Giordano, V.
    Palma, G.
    Luciano, A.
    Bruzzese, F.
    Zito, F. M.
    Montella, M.
    Franco, R.
    Scherillo, M.
    Quagliariello, V.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [9] Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-kB signaling pathway in diabetic rats
    Li, Jianping
    Liu, Xia
    Wu, Yuzhen
    Ji, Wei
    Tian, Qinghua
    Li, Shichen
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 634 : 75 - 82
  • [10] The stems of Syringa oblata Lindl. exert cardioprotective effects against acute myocardial ischemia by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome signaling pathways in mice
    Xu, Jixuan
    Kang, Lulu
    Tai, Badalahu
    Liu, Changxin
    Zhang, Zefeng
    Ding, Qiuyuan
    Yang, Guodong
    Shen, Yiru
    Chai, Xingyun
    Gao, Xiaoli
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 344
12345