Fermented milks with specific Lactobacillus spp. with potential cardioprotective effects

被引:3
|
作者
Zambrano-Cervantes, Miriam [1 ]
Gonzalez-Cordova, Aaron F. [1 ]
Hernandez-Mendoza, Adrian [1 ]
Beltran-Barrientos, Lilia M. [1 ]
Rendon-Rosales, Miguel A. [1 ]
Manzanarez-Quin, Carmen G. [1 ]
Torres-Llanez, Maria J. [1 ]
Vallejo-Cordoba, Belinda [1 ]
机构
[1] Ctr Invest Aimentac & Desarrollo AC CIAD AC, Carretera Gustavo Enrique Astiazaran Rosas 46, Hermosillo 833041, Sonora, Mexico
来源
关键词
Hypertension; Thrombosis; Cholesterol micelles; Fermented milks; Bioactive peptides; IN-VITRO; SPECTROPHOTOMETRIC ASSAY; ANTITHROMBOTIC ACTIVITY; INHIBITORY PEPTIDES; PROTEIN HYDROLYSATE; MOLECULAR DOCKING; SOY PROTEIN; IDENTIFICATION; PRESSURE; ACIDS;
D O I
10.1007/s13197-023-05715-1
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
In vitro and in vivo studies have reported the potential cardioprotective effects of fermented milks (FM). The aim of the present study was to evaluate the inhibitory activities of angiotensin converting enzyme (ACE), thrombin enzyme (TI) and micellar solubility of cholesterol of FM after 24 and 48 h of fermentation with Limosilactobacillus fermentum (J20, J23, J28 and J38), Lactiplantibacillus plantarum (J25) or Lactiplantibacillus pentosus (J34 and J37) exposed to simulated gastrointestinal digestion. Results showed that FM with J20 and J23 at 48 h of fermentation presented significantly (p < 0.05) higher degree of hydrolysis than other FM, and were not significantly different (p > 0.05) between them. Conversely, peptide relative abundance was significantly (p < 0.05) higher in FM with J20 than FM with J23. Moreover, IC50 (protein concentration necessary to inhibit enzyme activity by 50%) for ACE inhibition were 0.33 and 0.5 mg/mL for FM with J20 and J23, respectively. For TI inhibition, the IC50 were 0.3 and 0.24 mg/mL for FM with J20 and J23, respectively. Results exhibited 51 and 74% inhibition of micellar solubility cholesterol for FM with J20 and J23, respectively. Therefore, these results showed that not only peptide abundance, but also specific peptides might be responsible for these potential cardioprotective effects.
引用
收藏
页码:1749 / 1760
页数:12
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