Preclinical development of PKMYT1 and WEE1 inhibitor combinations

被引:0
|
作者
Gallo, David
Shah, Fenil
Stocco, Rino
Baruah, Prasamit
Fourtounis, Jimmy
Kryczka, Rosie
Hyer, Marc L.
Roulston, Anne
Marshall, C. Gary
Zimmermann, Michal
Morris, Stephen
Zinda, Michael
机构
关键词
D O I
10.1158/1535-7163.TARG-23-A023
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Abstract A
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Development and Characterization of a Wee1 Kinase Degrader
    Li, Zhengnian
    Pinch, Benika J.
    Olson, Calla M.
    Donovan, Katherine A.
    Nowak, Radosaw P.
    Mills, Caitlin E.
    Scott, David A.
    Doctor, Zainab M.
    Eleuteri, Nicholas A.
    Chung, Mirra
    Sorger, Peter K.
    Fischer, Eric S.
    Gray, Nathanael S.
    CELL CHEMICAL BIOLOGY, 2020, 27 (01) : 57 - +
  • [22] Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306
    Szychowski, Janek
    Papp, Robert
    Dietrich, Evelyne
    Liu, Bingcan
    Vallee, Frederic
    Leclaire, Marie-Eve
    Fourtounis, Jimmy
    Martino, Giovanni
    Perryman, Alexander L.
    Pau, Victor
    Yin, Shou Yun
    Mader, Pavel
    Roulston, Anne
    Truchon, Jean-Francois
    Marshall, C. Gary
    Diallo, Mohamed
    Duffy, Nicole M.
    Stocco, Rino
    Godbout, Claude
    Bonneau-Fortin, Alexanne
    Kryczka, Rosie
    Bhaskaran, Vivek
    Mao, Daniel
    Orlicky, Stephen
    Beaulieu, Patrick
    Turcotte, Pascal
    Kurinov, Igor
    Sicheri, Frank
    Mamane, Yael
    Gallant, Michel
    Black, W. Cameron
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (15) : 10251 - 10284
  • [23] Cdk1-dependent regulation of the mitotic inhibitor Wee1
    Harvey, SL
    Charlet, A
    Haas, W
    Gygi, SP
    Kellogg, DR
    CELL, 2005, 122 (03) : 407 - 420
  • [24] SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition
    Xiaomei Zhu
    Qunshu Su
    Haiyuan Xie
    Lizhi Song
    Fan Yang
    Dandan Zhang
    Binghong Wang
    Shixian Lin
    Jun Huang
    Mengjie Wu
    Ting Liu
    Nature Chemical Biology, 2023, 19 : 585 - 595
  • [25] SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition
    Zhu, Xiaomei
    Su, Qunshu
    Xie, Haiyuan
    Song, Lizhi
    Yang, Fan
    Zhang, Dandan
    Wang, Binghong
    Lin, Shixian
    Huang, Jun
    Wu, Mengjie
    Liu, Ting
    NATURE CHEMICAL BIOLOGY, 2023, 19 (05) : 585 - +
  • [26] Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy
    Guertin, Amy D.
    Li, Jing
    Liu, Yaping
    Hurd, Melissa S.
    Schuller, Alwin G.
    Long, Brian
    Hirsch, Heather A.
    Feldman, Igor
    Benita, Yair
    Toniatti, Carlo
    Zawel, Leigh
    Fawell, Stephen E.
    Gilliland, D. Gary
    Shumway, Stuart D.
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (08) : 1442 - 1452
  • [27] Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in patient-derived glioblastoma stem-like cells
    Toledo, Chad
    Yu, Ding
    Hoellerbauer, Pia
    Davis, Ryan
    Basom, Ryan
    Girard, Emily
    Corrin, Philip
    Bolouri, Hamid
    Davison, Jerry
    Zhang, Qing
    Nam, Do-Hyun
    Lee, Jeongwu
    Pollard, Steven
    Delrow, Jeffery
    Clurman, Bruce
    Olson, James
    Paddison, Patrick
    CANCER RESEARCH, 2016, 76
  • [28] Discovery and development of a potent and highly selective WEE1 inhibitor IMP7068
    Cai, Sui Xiong
    Ma, Ning
    Wang, Xiaozhu
    Jiang, Yangzhen
    Zhang, Hongxia
    Guo, Mingchuan
    Zhou, Ruiyu
    Tian, Ye Edward
    CANCER RESEARCH, 2023, 83 (07)
  • [29] Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy
    Fu, Siqing
    Wang, Yudong
    Keyomarsi, Khandan
    Meric-Bernstein, Funda
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (09) : 741 - 751
  • [30] Antitumor effect of Wee1 inhibitor in gastric cancer cells
    Kim, Seongyeong
    Min, Ahrum
    Kim, So Hyeon
    Ha, Dong Hyeon
    Jang, Hyemin
    Kim, Yu Jin
    Kim, Hee Jun
    Lee, Kyung-Hun
    Kim, Tae-Yong
    Oh, Do-Youn
    Bang, Yung-Jue
    Im, Seock-Ah
    CANCER RESEARCH, 2017, 77