Discovery and development of a potent and highly selective WEE1 inhibitor IMP7068

被引：2
|
作者：
Cai, Sui Xiong
Ma, Ning
Wang, Xiaozhu
Jiang, Yangzhen
Zhang, Hongxia
Guo, Mingchuan
Zhou, Ruiyu
Tian, Ye Edward
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-3091
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3091
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Safety, pharmacokinetic (PK), and pharmacodynamic profiles of the WEE1 inhibitor IMP7068 in patients (pts) with advanced solid tumors
    Lin, C-C.
    Grewal, J.
    Sommerhalder, D.
    Bai, L-Y.
    Li, G.
    Schneider, R.
    Shen, L.
    Yeh, Y-M.
    Yin, R.
    Hsu, H-C.
    Baranda, J. C.
    Hsieh, C-Y.
    Cai, S. X.
    Tian, Y. E.
    Ma, N.
    Xia, H.
    Zhang, C.
    Li, B.
    Zhang, M.
    Yu, Z.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S760 - S761
  • [2] A phase 1 dose-escalation and -expansion study of IMP7068, a WEE1 inhibitor, in patients with advanced solid tumors.
    Lin, Chia-Chi
    Grewal, Jaspreet Singh
    Sommerhalder, David
    Strauss, James Fredric
    Bai, Li-Yuan
    Shen, Lin
    Yeh, Yu-Min
    Hsieh, Chih-Yi
    Cai, Sui Xiong
    Tian, Ye Edward
    Xia, Huan
    Zhang, Congcong
    Li, Baoyue
    Zhang, Ming
    Ma, Ning
    Zhao, Liping
    Ma, Jie
    Shi, Huiyan
    Yu, Zhixin
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [3] Phase I, multi-center, dose-escalation and dose-expansion study of IMP7068, a WEE1 inhibitor, in patients with advanced solid tumors
    Lin, C-C.
    Grewal, J.
    Baranda, J. C.
    Schneider, R. E.
    Zhang, J.
    Bai, L-Y.
    Yeh, Y-M.
    Sommerhalder, D.
    Li, G.
    Shen, L.
    Hsu, H-C.
    Alese, O.
    Yin, R.
    Hsieh, C-Y.
    Cai, S. X.
    Tian, Y. E.
    Xia, H.
    Li, B.
    Zhang, M.
    Zhang, C.
    ANNALS OF ONCOLOGY, 2023, 34 : S466 - S466
  • [4] Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer
    Huang, Peter Q.
    Boren, Brant C.
    Hegde, Sayee G.
    Liu, Hui
    Unni, Aditya K.
    Abraham, Sunny
    Hopkins, Chad D.
    Paliwal, Sunil
    Samatar, Ahmed A.
    Li, Jiali
    Bunker, Kevin D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (17) : 13004 - 13024
  • [5] WEE1 Inhibitor: Clinical Development
    Anthony Kong
    Hisham Mehanna
    Current Oncology Reports, 2021, 23
  • [6] WEE1 Inhibitor: Clinical Development
    Kong, Anthony
    Mehanna, Hisham
    CURRENT ONCOLOGY REPORTS, 2021, 23 (09)
  • [7] A novel, potent and selective inhibitor of Wee1 with robust antitumor activity in various cancer xenograph models
    Gavory, Gerald
    O'Dowd, Colin
    Burkamp, Frank
    Rountree, Shane
    Rozycka, Ewelina
    Boyd, Caroline
    Gorges, Beronia
    Burton, Stephanie
    Wilkinson, Andy
    Shepherd, Steven
    Janssen, Dominic
    McFarland, Mary
    Rountree, Shane
    Harrison, Tim
    CANCER RESEARCH, 2016, 76
  • [8] Discovery and development of IMP1734 (EIK1003), a potent and selective PARP1 inhibitor
    Cai, S. X.
    Ma, N.
    Wang, X.
    Zhao, Y.
    Zhou, R.
    Jiang, Y.
    Chen, M.
    Tian, Y. E.
    Krishnan, S.
    Dumble, M.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S135 - S135
  • [9] Preclinical development of PKMYT1 and WEE1 inhibitor combinations
    Gallo, David
    Shah, Fenil
    Stocco, Rino
    Baruah, Prasamit
    Fourtounis, Jimmy
    Kryczka, Rosie
    Hyer, Marc L.
    Roulston, Anne
    Marshall, C. Gary
    Zimmermann, Michal
    Morris, Stephen
    Zinda, Michael
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [10] WEE1 kinase inhibitor shows promise
    Sidaway, Peter
    NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (10) : 593 - 593
12345