Novel One-Pot Pseudo-Five-Component Green Synthesis and Biological Activities In Vitro of 5,5′-(Arylmethylene)Bis (4-Hydroxythiazol-2(3H)-One) Using Triton-X-100 as High Efficient Catalytic System

被引：3
|
作者：
Hemmati, Sana [1 ]
Heravi, Mohammad Reza Poor [2 ]
Nami, Navabeh [1 ]
Khalilzadeh, Mohammad A. [1 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Qaemshahr Branch, Qaemshahr, Iran
[2] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 03期
关键词：
5,5 '-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one); Triton X-100; three-component reaction; nonionic surfactant; thiourea; IONIC LIQUID; MULTICOMPONENT SYNTHESIS; ORGANIC-REACTIONS; AQUEOUS-MEDIA; CONDENSATION; CHLORIDE; SILICA; FOCUS;
D O I：
10.1080/10406638.2022.2048033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of 5,5'-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one) by a three-component condensation of an aldehyde, monochlroacetic acid and thiourea in the presence of a nonionic surfactant Triton X-100 catalyst at room temperature in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-friendliness. All the newly-synthesized compounds (4a-r) exhibited moderate in vitro antibacterial and antifungal activities. [GRAPHICS] .
引用
收藏
页码：2540 / 2552
页数：13
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