A Green and Efficient One-Pot Pseudo-Five-Component Reaction for Synthesis of Bis(pyrazol-5-ol) Derivatives via Tandem Cyclocondensation-Knoevenagel-Michael Reaction

被引：18
|
作者：
Yang, Cheng [1 ,2 ]
Liu, Peng-Ze [1 ,2 ]
Xu, Da-Zhen [1 ,2 ]
机构：
[1] Nankai Univ, Natl Engn Res Ctr Pesticide Tianjin, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 03期
基金：
中国国家自然科学基金;
关键词：
aqueous media; bis(pyrazol-5-ol)s; ionic liquid; multi-component tandem reactions; recyclability; C-TETHERED BISPYRAZOL-5-OLS; IONIC LIQUID; MULTICOMPONENT REACTIONS; ORGANIC-REACTIONS; HIGHLY EFFICIENT; AQUEOUS-MEDIA; 4,4'-(ARYLMETHYLENE)BIS(3-METHYL-1H-PYRAZOL-5-OL) DERIVATIVES; ACETOACETATE DERIVATIVES; RECYCLABLE CATALYST; PHENYL HYDRAZINE;
D O I：
10.1002/slct.201601801
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, green and efficient approach for one-pot pseudo-five-component synthesis of the 4,4'-(arylmethylene) bis(1H-pyrazol-5-ol) derivatives from hydrazines, dialkyl acetylenedicarboxylats/beta-ketoesters and aromatic aldehydes catalyzed by Dabco-base ionic liquids in aqueous media has been successfully developed. All the reactions were performed under 3 mol% of ionic liquid catalyst, and afforded the corresponding bis(pyrazol-5-ol)s in excellent yields (81-98 %). This method also offers several other notable advantages, such as environmental friendliness, short reaction times, easy workup and reusability of the inexpensive catalyst.
引用
收藏
页码：1232 / 1236
页数：5
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