Novel One-Pot Pseudo-Five-Component Green Synthesis and Biological Activities In Vitro of 5,5′-(Arylmethylene)Bis (4-Hydroxythiazol-2(3H)-One) Using Triton-X-100 as High Efficient Catalytic System

被引：3

作者：

Hemmati, Sana ^{[1
]}

Heravi, Mohammad Reza Poor ^{[2
]}

Nami, Navabeh ^{[1
]}

Khalilzadeh, Mohammad A. ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Qaemshahr Branch, Qaemshahr, Iran

[2] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 03期

关键词：

5,5 '-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one); Triton X-100; three-component reaction; nonionic surfactant; thiourea; IONIC LIQUID; MULTICOMPONENT SYNTHESIS; ORGANIC-REACTIONS; AQUEOUS-MEDIA; CONDENSATION; CHLORIDE; SILICA; FOCUS;

D O I：

10.1080/10406638.2022.2048033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 5,5'-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one) by a three-component condensation of an aldehyde, monochlroacetic acid and thiourea in the presence of a nonionic surfactant Triton X-100 catalyst at room temperature in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-friendliness. All the newly-synthesized compounds (4a-r) exhibited moderate in vitro antibacterial and antifungal activities. [GRAPHICS] .

引用

页码：2540 / 2552

页数：13

共 27 条

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[12] One-Pot Syntheses with 2-Substituted 6-Aminopyrimidin-4(3H)-ones: New 5-Aryl-5,8,9,10-tetrahydropyrimido[4,5-b]-quinoline-4,6(3H,7H)-diones and 5,5′-(Arylmethylene)-bis[6-amino-2-methylpyrimidin-4(3H)-ones]
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[14] Sulfonated Honeycomb Coral (HC-SO3H): a new, green and highly efficient heterogeneous catalyst for the rapid one-pot pseudo-five component synthesis of 4,4′-(aryl methylene) bis(3-methyl-1H-pyrazol-5-ol)s
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