Susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida and Streptococcus suis Isolated from Pigs in Hungary between 2018 and 2021

被引:3
|
作者
Somogyi, Zoltan [1 ,2 ]
Mag, Patrik [1 ,2 ]
Simon, Reka [1 ]
Kerek, Adam [1 ,2 ]
Makrai, Laszlo [2 ,3 ]
Biksi, Imre [4 ,5 ]
Jerzsele, Akos [1 ,2 ]
机构
[1] Univ Vet Med, Dept Pharmacol & Toxicol, Istvan Str 2, H-1078 Budapest, Hungary
[2] Univ Vet Med, Natl Lab Infect Anim Dis Antimicrobial Resistance, H-1078 Budapest, Hungary
[3] Univ Vet Med, Dept Microbiol & Infect Dis, Istvan Str 2, H-1078 Budapest, Hungary
[4] Univ Vet Med, Dept Pathol, Istvan Str 2, H-1078 Budapest, Hungary
[5] SCG Diagnost Ltd, HU-2437 Delegyhaza, Hungary
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 08期
关键词
Actinobacillus pleuropneumoniae; Pasteurella multocida; Streptococcus suis; MIC; antibacterial agents; swine; ANTIMICROBIAL SUSCEPTIBILITY; ESCHERICHIA-COLI; EDIBLE TISSUES; UNITED-STATES; RESISTANCE; DISEASE; CANADA;
D O I
10.3390/antibiotics12081298
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Porcine respiratory disease complex (PRDC) has been a major animal health, welfare, and economic problem in Hungary; therefore, great emphasis should be put on both the prevention and control of this complex disease. As antibacterial agents are effective tools for control, antibiotic susceptibility testing is indispensable for the proper implementation of antibacterial therapy and to prevent the spread of resistance. The best method for this is to determine the minimum inhibitory concentration (MIC) by the broth microdilution method. In our study, we measured the MIC values of 164 Actinobacillus pleuropneumoniae, 65 Pasteurella multocida, and 118 Streptococcus suis isolates isolated from clinical cases against the following antibacterial agents: amoxicillin, ceftiofur, cefquinome, oxytetracycline, doxycycline, tylosin, tilmicosin, tylvalosin, tulathromycin, lincomycin, tiamulin, florfenicol, colistin, enrofloxacin, and sulfamethoxazole-trimethoprim. Outstanding efficacy against A. pleuropneumoniae isolates was observed with ceftiofur (100%) and tulathromycin (100%), while high levels of resistance were observed against cefquinome (92.7%) and sulfamethoxazole-trimethoprim (90.8%). Ceftiofur (98.4%), enrofloxacin (100%), florfenicol (100%), and tulathromycin (100%) were found to be highly effective against P. multocida isolates, while 100% resistance was detected against the sulfamethoxazole-trimethoprim combination. For the S. suis isolates, only ceftiofur (100%) was not found to be resistant, while the highest rate of resistance was observed against the sulfamethoxazole-trimethoprim combination (94.3%). An increasing number of studies report multi-resistant strains of all three pathogens, making their monitoring a high priority for animal and public health.
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