One-Pot N -α-C(sp3 )- H Bond Functionalisation Cascade for the Synthesis of Polysubstituted Imidazoles

被引：2

作者：

Kadu, Vikas D. ^{[1
]}

Sankala, Naga Chandradudu ^{[2
]}

Hublikar, Mahesh G. ^{[1
]}

Bansode, Shahaji I. ^{[1
]}

Bhosale, Raghunath B. ^{[1
]}

机构：

[1] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India

[2] Rayalseema Univ, Dept Chem, Coll Engn, Kurnool 518002, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 14期

关键词：

imidazoles; iron catalysis; oxidative coupling; N -alpha-C(sp(3) )- H functionalisation; one-pot reaction; TETRASUBSTITUTED IMIDAZOLES; PHOTOPHYSICAL PROPERTIES; SUBSTITUTED IMIDAZOLES; EFFICIENT SYNTHESIS; ANTIFUNGAL AGENTS; IRON CATALYSIS; METAL; AMINES; ANTIBACTERIAL; BENZYLAMINES;

D O I：

10.1055/s-0043-1763690

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot eco-friendly oxidative N-alpha-C(sp(3))-H bond functionalisation of arylmethylamines for the synthesis of tetrasubstituted imidazoles is demonstrated. The substrate scope of these amines has been well-explored with different substrates, such as 1,2-diketones, an alpha-hydroxy ketone and phenylacetophenone. In the presence of FeCl(3 )catalyst and green oxidant O-2, the easily accessible substrates afforded tetrasubstituted imidazoles in up to 94% yield.

引用

页码：2277 / 2283

页数：7

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