One-Pot N -α-C(sp3 )- H Bond Functionalisation Cascade for the Synthesis of Polysubstituted Imidazoles

被引：2
|
作者：
Kadu, Vikas D. [1 ]
Sankala, Naga Chandradudu [2 ]
Hublikar, Mahesh G. [1 ]
Bansode, Shahaji I. [1 ]
Bhosale, Raghunath B. [1 ]
机构：
[1] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India
[2] Rayalseema Univ, Dept Chem, Coll Engn, Kurnool 518002, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 14期
关键词：
imidazoles; iron catalysis; oxidative coupling; N -alpha-C(sp(3) )- H functionalisation; one-pot reaction; TETRASUBSTITUTED IMIDAZOLES; PHOTOPHYSICAL PROPERTIES; SUBSTITUTED IMIDAZOLES; EFFICIENT SYNTHESIS; ANTIFUNGAL AGENTS; IRON CATALYSIS; METAL; AMINES; ANTIBACTERIAL; BENZYLAMINES;
D O I：
10.1055/s-0043-1763690
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot eco-friendly oxidative N-alpha-C(sp(3))-H bond functionalisation of arylmethylamines for the synthesis of tetrasubstituted imidazoles is demonstrated. The substrate scope of these amines has been well-explored with different substrates, such as 1,2-diketones, an alpha-hydroxy ketone and phenylacetophenone. In the presence of FeCl(3 )catalyst and green oxidant O-2, the easily accessible substrates afforded tetrasubstituted imidazoles in up to 94% yield.
引用
收藏
页码：2277 / 2283
页数：7
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