Stress regulates Alzheimer's disease progression via selective enrichment of CD8+T cells

被引：2
|
作者：
Feng, Yilin [1 ,2 ]
Fan, Jiaqi [1 ,2 ,3 ]
Cheng, Yifan [1 ,2 ]
Dai, Qionghai [2 ]
Ma, Shaohua [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch SIGS, Shenzhen 518055, Peoples R China
[2] Tsinghua Berkeley Shenzhen Inst TBSI, Shenzhen 518055, Peoples R China
[3] Tsinghua Univ, Inst Brain & Cognit Sci, Beijing 100084, Peoples R China
来源：
CELL REPORTS | 2023年 / 42卷 / 10期
基金：
中国国家自然科学基金;
关键词：
AMYLOID-BETA-PROTEIN; SOCIAL DEFEAT STRESS; T-CELLS; IMMUNE ACTIVATION; MOUSE MODEL; A-BETA; BRAIN; INTERLEUKIN-6; EXPRESSION; NEUROINFLAMMATION;
D O I：
10.1016/j.celrep.2023.113313
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This study investigates stress's impact on Alzheimer's disease (AD) using male APP/PS1 transgenic mice. Negative stressors (chronic social defeat, restraint) and positive hedonia (environmental enrichment, EE) were applied. Stress worsens AD pathology, while EE slows progression. Brain RNA sequencing reveals interleukin-6 (IL-6) and IL-10 as key stress-related AD regulators. Flow cytometry shows that the CD8+/ CD4+ T cell ratio shifts in response to stress exposure and EE. Stress exposure increases CD8+/CD4+ ratio, opposite to EE. Depletion and enrichment of CD8+ T cells both accelerate AD, indicating immune intervention's negative impact. Stress management and balanced immunity may aid AD therapy, highlighting novel potential treatment.
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页数：24
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