Stress regulates Alzheimer's disease progression via selective enrichment of CD8+T cells

被引：2

作者：

Feng, Yilin ^{[1
,2
]}

Fan, Jiaqi ^{[1
,2
,3
]}

Cheng, Yifan ^{[1
,2
]}

Dai, Qionghai ^{[2
]}

Ma, Shaohua ^{[1
,2
,3
]}

机构：

[1] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch SIGS, Shenzhen 518055, Peoples R China

[2] Tsinghua Berkeley Shenzhen Inst TBSI, Shenzhen 518055, Peoples R China

[3] Tsinghua Univ, Inst Brain & Cognit Sci, Beijing 100084, Peoples R China

来源：

CELL REPORTS | 2023年 / 42卷 / 10期

基金：

中国国家自然科学基金;

关键词：

AMYLOID-BETA-PROTEIN; SOCIAL DEFEAT STRESS; T-CELLS; IMMUNE ACTIVATION; MOUSE MODEL; A-BETA; BRAIN; INTERLEUKIN-6; EXPRESSION; NEUROINFLAMMATION;

D O I：

10.1016/j.celrep.2023.113313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study investigates stress's impact on Alzheimer's disease (AD) using male APP/PS1 transgenic mice. Negative stressors (chronic social defeat, restraint) and positive hedonia (environmental enrichment, EE) were applied. Stress worsens AD pathology, while EE slows progression. Brain RNA sequencing reveals interleukin-6 (IL-6) and IL-10 as key stress-related AD regulators. Flow cytometry shows that the CD8+/ CD4+ T cell ratio shifts in response to stress exposure and EE. Stress exposure increases CD8+/CD4+ ratio, opposite to EE. Depletion and enrichment of CD8+ T cells both accelerate AD, indicating immune intervention's negative impact. Stress management and balanced immunity may aid AD therapy, highlighting novel potential treatment.

引用

页数：24

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