Iodotriphenylphosphonium iodide mediated deprotection of aryl alkyl ethers under metal-free and neutral conditions

被引：0
|
作者：
Zhang, Minxiang [1 ]
Xie, Hongyan [1 ]
Yan, Zhaohua [1 ]
Fang, Xueyu [1 ]
Fang, Yongsong [2 ]
机构：
[1] Nanchang Univ, Coll Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China
[2] Zhejiang Charioteer Pharmaceut Co Ltd, Xianju 317321, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 121卷
基金：
中国国家自然科学基金;
关键词：
Iodotriphenylphosphonium iodide; Aryl alkyl ethers; Deprotection; Metal -free conditions; Phenols; VERSATILE REAGENTS; SYNTHETIC METHODS; BOND-CLEAVAGE; BENZYL ETHERS; IONIC LIQUID; TRIPHENYLPHOSPHINE; EPOXIDES; ALLYL; DEALKYLATION; DEOXYGENATION;
D O I：
10.1016/j.tetlet.2023.154460
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient method for the deprotection of aryl alkyl ethers under metal-free and neutral condi-tions was developed by iodotriphenylphosphonium iodide [Ph3P+I]I- formed in situ through the reaction of equimolar PPh3 and I2. A variety of aryl alkyl ethers including aryl methyl/allyl/benzyl/ethyl/n-propyl/ i-propyl/n-butyl ethers can all be highly efficiently deprotected to release the corresponding phenols in good to excellent yields.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：4
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