Is Lactoferrin Supplementation Beneficial for All Preterm Infants?

被引：0
|
作者：
Nayak, Amrita [1 ]
Tiozzo, Caterina [1 ,2 ]
Lin, Xinhua [2 ]
Mejia, Claudia [2 ]
Gurzenda, Ellen [2 ]
Kim, Maureen [1 ]
Hanna, Nazeeh [1 ,2 ]
机构：
[1] NYU, Dept Pediat, Langone Hosp Long Isl, Mineola, NY 11501 USA
[2] NYU, Women & Children Res Lab, Long Isl Sch Med, Mineola, NY 11501 USA
来源：
AMERICAN JOURNAL OF PERINATOLOGY | 2023年 / 40卷 / 06期
关键词：
human milk; necrotizing enterocolitis; nutrition; lactoferrin; human milk fortifier; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT INFANTS; LATE-ONSET SEPSIS; HUMAN-MILK; BOVINE LACTOFERRIN; BREAST-MILK; NECROTIZING ENTEROCOLITIS; DOUBLE-BLIND; PREVENTION; MOTHERS;
D O I：
10.1055/s-0041-1730433
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective Human milk (HM) has antibacterial properties due to the presence of immune-modulators, including lactoferrin (LF). This study will determine effect(s) of HM maturation, fortification, and storage conditions on LF levels and its antibacterial properties. Study Design HM samples ( n = 30) were obtained from preterm and term mothers. The LF levels were analyzed by ELISA, and the antibacterial activity was measured after inoculation with Escherichia coli . Results The highest level of LF in preterm HM was observed in the first week of lactation. However, storage of preterm HM at 4 degrees C decreased LF levels significantly. Both LF levels and antibacterial activity in preterm HM was lower compared with term HM, but significantly higher than donor HM even after HM-based fortification. LF supplementation of donor HM improved its antibacterial activity. Conclusion Preterm infants fed donor HM, formula, or stored HM at 4 degrees C may benefits from LF supplementation to improve HM antibacterial properties.
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收藏
页码：680 / 687
页数：8
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