Is Lactoferrin Supplementation Beneficial for All Preterm Infants?

被引：0

作者：

Nayak, Amrita ^{[1
]}

Tiozzo, Caterina ^{[1
,2
]}

Lin, Xinhua ^{[2
]}

Mejia, Claudia ^{[2
]}

Gurzenda, Ellen ^{[2
]}

Kim, Maureen ^{[1
]}

Hanna, Nazeeh ^{[1
,2
]}

机构：

[1] NYU, Dept Pediat, Langone Hosp Long Isl, Mineola, NY 11501 USA

[2] NYU, Women & Children Res Lab, Long Isl Sch Med, Mineola, NY 11501 USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2023年 / 40卷 / 06期

关键词：

human milk; necrotizing enterocolitis; nutrition; lactoferrin; human milk fortifier; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT INFANTS; LATE-ONSET SEPSIS; HUMAN-MILK; BOVINE LACTOFERRIN; BREAST-MILK; NECROTIZING ENTEROCOLITIS; DOUBLE-BLIND; PREVENTION; MOTHERS;

D O I：

10.1055/s-0041-1730433

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective Human milk (HM) has antibacterial properties due to the presence of immune-modulators, including lactoferrin (LF). This study will determine effect(s) of HM maturation, fortification, and storage conditions on LF levels and its antibacterial properties. Study Design HM samples ( n = 30) were obtained from preterm and term mothers. The LF levels were analyzed by ELISA, and the antibacterial activity was measured after inoculation with Escherichia coli . Results The highest level of LF in preterm HM was observed in the first week of lactation. However, storage of preterm HM at 4 degrees C decreased LF levels significantly. Both LF levels and antibacterial activity in preterm HM was lower compared with term HM, but significantly higher than donor HM even after HM-based fortification. LF supplementation of donor HM improved its antibacterial activity. Conclusion Preterm infants fed donor HM, formula, or stored HM at 4 degrees C may benefits from LF supplementation to improve HM antibacterial properties.

引用

页码：680 / 687

页数：8

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