Indole alkaloids from endophytic fungus Robillarda sessilis and their antibacterial activity

被引：1

作者：

Huang, Zediao ^{[1
]}

Wu, Di ^{[1
]}

Liu, Xueqiong ^{[1
]}

Liu, Qingpei ^{[1
]}

Han, Xiaole ^{[2
,3
]}

Wang, Wenjing ^{[1
]}

Yang, Xiaolong ^{[1
]}

机构：

[1] South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan, Peoples R China

[2] South Cent Minzu Univ, Key Lab Catalysis & Energy Mat Chem, Minist Educ, Wuhan 430074, Peoples R China

[3] South Cent Minzu Univ, Hubei Key Lab Catalysis & Mat Sci, Wuhan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年 / 39卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Indole alkaloids; Robillarda sessilis; antibacterial activity; molecule docking;

D O I：

10.1080/14786419.2023.2297853

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three undescribed indole alkaloids, fusarindoles F and G (1 and 2), and chlamydosporin B (3), together with five known compounds (4-8) were isolated from Robillarda sessilis. Their structures were elucidated based on NMR, UV, HRESIMS, and ECD calculation. Fusarindole F (1) own unusual asymmetric bis-indole structure. Compounds 5, 6, 7 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 12.5 mu g/mL. According to molecular docking experiment, the target proteins of compound 7 against methicillin-resistant S. aureus may be ELANE, MAOB and STAT3.

引用

页码：1156 / 1165

页数：10

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