Indole alkaloids from endophytic fungus Robillarda sessilis and their antibacterial activity

被引：1
|
作者：
Huang, Zediao [1 ]
Wu, Di [1 ]
Liu, Xueqiong [1 ]
Liu, Qingpei [1 ]
Han, Xiaole [2 ,3 ]
Wang, Wenjing [1 ]
Yang, Xiaolong [1 ]
机构：
[1] South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan, Peoples R China
[2] South Cent Minzu Univ, Key Lab Catalysis & Energy Mat Chem, Minist Educ, Wuhan 430074, Peoples R China
[3] South Cent Minzu Univ, Hubei Key Lab Catalysis & Mat Sci, Wuhan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2025年 / 39卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Indole alkaloids; Robillarda sessilis; antibacterial activity; molecule docking;
D O I：
10.1080/14786419.2023.2297853
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Three undescribed indole alkaloids, fusarindoles F and G (1 and 2), and chlamydosporin B (3), together with five known compounds (4-8) were isolated from Robillarda sessilis. Their structures were elucidated based on NMR, UV, HRESIMS, and ECD calculation. Fusarindole F (1) own unusual asymmetric bis-indole structure. Compounds 5, 6, 7 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 12.5 mu g/mL. According to molecular docking experiment, the target proteins of compound 7 against methicillin-resistant S. aureus may be ELANE, MAOB and STAT3.
引用
收藏
页码：1156 / 1165
页数：10
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