TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo

被引：3
|
作者：
Liang, Apeng
Dong, Shengli
Liu, Guangbin
Guo, Zhengfei
Li, Meihua
Han, Shuaibo
Cao, Yundi
Tu, Yian
Zhou, Chao
Yu, Yu
Xiao, Linglin
Huang, Wei
Yang, Xinlong
Fang, Lian
Li, Haoyun
Niu, Chengshan
Jiang, Mingyu
Xing, Feng
Chen, Shaoqing
Li, Jun
Wu, Yusheng
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-4491
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4491
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo
    Hirai, Hiroshi
    Takahashi-Suziki, Ikuko
    Shimomura, Toshiyasu
    Fukasawa, Kazuhiro
    Machida, Takumitsu
    Takaki, Toru
    Kobayashi, Makiko
    Eguchi, Tomohiro
    Oki, Hiroko
    Arai, Tsuyoshi
    Ichikawa, Koji
    Hasako, Shinichi
    Kodera, Tsutomu
    Kawanishi, Nobuhiko
    Nakatsuru, Yoko
    Kotani, Hidehito
    Iwasawa, Yoshikazu
    INVESTIGATIONAL NEW DRUGS, 2011, 29 (04) : 534 - 543
  • [32] Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo
    Hiroshi Hirai
    Ikuko Takahashi-Suziki
    Toshiyasu Shimomura
    Kazuhiro Fukasawa
    Takumitsu Machida
    Toru Takaki
    Makiko Kobayashi
    Tomohiro Eguchi
    Hiroko Oki
    Tsuyoshi Arai
    Koji Ichikawa
    Shinichi Hasako
    Tsutomu Kodera
    Nobuhiko Kawanishi
    Yoko Nakatsuru
    Hidehito Kotani
    Yoshikazu Iwasawa
    Investigational New Drugs, 2011, 29 : 534 - 543
  • [33] Discovery of a first-in-class TEAD inhibitor which directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma
    Kaneda, Ayumi
    Seike, Toshihiro
    Uemori, Takeshi
    Myojo, Kensuke
    Aida, Kensuke
    Danjo, Tomohiro
    Nakajima, Takahiro
    Yamaguchi, Daisuke
    Hamada, Tomoko
    Tsuji, Yoshiro
    Hamaguchi, Kaori
    Yasunaga, Mai
    Otsubo, Nobumasa
    Onodera, Hideyuki
    Nishiya, Yoichi
    Suzuki, Michihiko
    Saito, Junichi
    Ishii, Toshihiko
    Nakai, Ryuichiro
    CANCER RESEARCH, 2019, 79 (13)
  • [34] The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma
    Kaneda, Ayumi
    Seike, Toshihiro
    Danjo, Tomohiro
    Nakajima, Takahiro
    Otsubo, Nobumasa
    Yamaguchi, Daisuke
    Tsuji, Yoshiro
    Hamaguchi, Kaori
    Yasunaga, Mai
    Nishiya, Yoichi
    Suzuki, Michihiko
    Saito, Jun-ichi
    Yatsunami, Rie
    Nakamura, Satoshi
    Sekido, Yoshitaka
    Mori, Kiyotoshi
    AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 10 (12): : 4399 - 4415
  • [35] In vivo anti-tumor activity of ARRY-334543, a small molecule inhibitor of EGFR and ErbB-2.
    Pheneger, TM
    Woessner, R
    Lyssikatos, J
    Miknis, G
    Anderson, D
    Winski, S
    Lee, PA
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9026S - 9026S
  • [36] The anti-tumor effects of COX-2 inhibitor against malignant astrocytic tumor cells in vitro and in vivo
    Katayama, Kosuke
    Asano, Kenichiro
    Ohkuma, Hiroki
    BRAIN PATHOLOGY, 2019, 29 : 150 - 151
  • [37] Improved anti-tumor efficacy of chemotherapy by (-)Gossypol, a potent small molecule inhibitor of anti-apoptotic protein Bcl-XL.
    Xu, L
    Yang, DJ
    Wang, SM
    Tang, WH
    Coleska, ZN
    Liu, HP
    Wu, XH
    Ji, M
    Chen, JY
    Ling, Y
    Tomita, Y
    Lippman, ME
    CLINICAL CANCER RESEARCH, 2003, 9 (16) : 6155S - 6155S
  • [38] Novel Selective Orally Bioavailable Small Molecule PAK4 Allosteric Modulators (PAMs) Display Anti-Tumor Activity in Vitro and in Vivo in Hematological Malignancies
    Senapedis, William
    George, Ryan
    McCauley, Dilara
    Ellis, Joel
    Crochiere, Marsha
    Savona, Michael
    Shacham, Sharon
    Landesman, Yosef
    Baloglu, Erkan
    BLOOD, 2014, 124 (21)
  • [39] Novel small molecule HPK1 inhibitor induces immunogenic anti-tumor effects.
    Chaudhari, Sachin S.
    Bajpai, Malini
    Mandadi, Sravan
    Kattige, Vidya G.
    Thorat, Sandeep
    Potdar, Varada
    Pangre, Priyanka
    Sawant, Pooja
    Misra, Chandrasekhar
    Das, Subhadip
    Akarte, Atul
    Singh, Anuj
    Mahankali, Sandeep
    Lambade, Pandurang
    Das, Avratanu
    Patole, Raju
    Udupa, Venkatesha
    Sancheti, Pavankumar
    Pawar, Pramod K.
    Kakade, Somesh
    Vinod, K. R.
    Biswas, Nilanjana
    Shah, Heta
    Behera, Dayanidhi
    Jain, Pankaj
    Gowda, Nagaraj
    Iyer, Pravin S.
    CANCER RESEARCH, 2021, 81 (13)
  • [40] S-222611, a potent, orally active small molecule inhibitor of EGFR and HER2: In vivo antitumor effects
    Iguchi, Motofumi
    Tanaka, Hidekazu
    Wada, Tohru
    Hojo, Kanji
    Shinonome, Satomi
    Sato, Norihito
    Nezasa, Ken-ichi
    Orita, Satoshi
    Abe, Kenji
    Arimura, Akinori
    Matsuo, Yoshiyuki
    Kato, Akira
    CANCER RESEARCH, 2009, 69
12345