TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo

被引:3
|
作者
Liang, Apeng
Dong, Shengli
Liu, Guangbin
Guo, Zhengfei
Li, Meihua
Han, Shuaibo
Cao, Yundi
Tu, Yian
Zhou, Chao
Yu, Yu
Xiao, Linglin
Huang, Wei
Yang, Xinlong
Fang, Lian
Li, Haoyun
Niu, Chengshan
Jiang, Mingyu
Xing, Feng
Chen, Shaoqing
Li, Jun
Wu, Yusheng
机构
关键词
D O I
10.1158/1538-7445.AM2023-4491
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4491
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Potent small molecule TEAD inhibitors targeting the Hippo pathway exhibit antiproliferation in vitro and anti-tumor effect in vivo
    Amidon, Ben
    Syed, Sakeena
    Cavanaugh, Jill
    Frosch, Hyejin
    Natarajan, Prabitha
    Ecsedy, Jeffrey
    McGovern, Karen
    Castro, Alfredo C.
    CANCER RESEARCH, 2020, 80 (16)
  • [2] The Glutaminase Inhibitor Compound 968 Exhibits Potent In vitro and In vivo Anti-tumor Effects in Endometrial Cancer
    Guo, Hui
    Li, Wanhu
    Pan, Guoyou
    Wang, Cong
    Li, Dapeng
    Liu, Naifu
    Sheng, Xiugui
    Yuan, Lingqin
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2023, 23 (02) : 210 - 221
  • [3] Discovery of novel and potent TEAD inhibitors, orally available small molecules with anti-tumor activity in hippo pathway-dysregulated cancers
    Moon, Sungho
    Cho, Seon Yeon
    Kim, Minhye
    Beak, Soojeong
    Kim, Jinhyuk
    Kim, Yongchan
    Park, Sungil
    Kim, Jung-In
    Kim, Hanseong
    Lee, In Sang
    No, Kyoung Tai
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [4] Discovery and characterization of a new potent orally available CdC7 inhibitor with anti-tumor activity
    Montagnoli, A.
    Vanotti, E.
    Rainoldi, S.
    Marchesi, V.
    Ciavolella, A.
    Croci, V.
    Patton, V.
    Albanese, C.
    Santocanale, C.
    Moll, J.
    EJC SUPPLEMENTS, 2008, 6 (12): : 116 - 116
  • [5] In vitro and in vivo anti-tumor activity of ARQ 751, a potent and selective AKT inhibitor
    Yu, Yi
    Savage, Ronald E.
    Eathiraj, Sudharshan
    Hall, Terence
    Schwartz, Brian
    Abbadessa, Giovanni
    CANCER RESEARCH, 2016, 76
  • [6] Liraglutide exhibits potential anti-tumor effects on the progression of intrahepatic cholangiocarcinoma, in vitro and in vivo
    Trakoonsenathong, Ronnakrit
    Kunprom, Waritta
    Aphivatanasiri, Chaiwat
    Yueangchantuek, Padcharee
    Pimkeeree, Paslada
    Sorin, Supannika
    Khawkhiaw, Kullanat
    Chiu, Ching-Feng
    Okada, Seiji
    Wongkham, Sopit
    Saengboonmee, Charupong
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [7] Novel small molecule inhibitors of p97 demonstrate anti-tumor effects in vitro and in vivo
    Anderson, D.
    Djakovic, S.
    Kissvonsoly, S.
    Le Moigne, R.
    Rice, J.
    Rolfe, M.
    Soriano, F.
    Valle, E.
    Wang, J.
    Wong, S.
    Wustrow, D.
    Yakes, M.
    Yao, B.
    Zhou, H-J.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [8] AP24534: an orally active kinase inhibitor that targets multiple pro-angiogenic receptors and exhibits potent anti-tumor activity in vivo
    Rivera, V. M.
    DiRenzo, R.
    Berk, L.
    Wardwell, S.
    Ning, Y.
    Narasimhan, N. I.
    Xu, Q.
    Shakespeare, W. C.
    Wang, F.
    Clackson, T.
    EJC SUPPLEMENTS, 2008, 6 (12): : 174 - 174
  • [9] L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo
    Zhu, Mingfei
    Wang, Hong
    Wang, Chenglin
    Fang, Yanfen
    Zhu, Tong
    Zhao, Weili
    Dong, Xiaochun
    Zhang, Xiongwen
    FRONTIERS IN PHARMACOLOGY, 2019, 10
  • [10] CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity
    Sullivan, Kathleen M. C.
    Vilalta, Marta
    Ertl, Linda S.
    Wang, Yu
    Dunlap, Carolyn
    Ebsworth, Karen
    Zhao, Bin N.
    Li, Shijie
    Zeng, Yibin
    Miao, Zhenhua
    Fan, Pingchen
    Mali, Venkat
    Lange, Christopher
    McMurtrie, Darren
    Yang, Ju
    Lui, Rebecca
    Scamp, Ryan
    Chhina, Vicky
    Kumamoto, Alice
    Yau, Simon
    Dang, Ton
    Easterday, Ashton
    Liu, Shirley
    Miao, Shichang
    Charo, Israel
    Schall, Thomas J.
    Zhang, Penglie
    PLOS ONE, 2023, 18 (06):