Synthesis of Phosphorus(V)-Substituted Six-Membered N-Heterocycles: Recent Progress and Challenges

被引：4

作者：

Volkova, Yulia ^{[1
]}

Zavarzin, Igor ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

MOLECULES | 2023年 / 28卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

heterocycles; pyridine; pyridazine; pyrimidine; pyrazine; organophosphorus compounds; CATALYZED ASYMMETRIC HYDROGENATION; CHIRAL DIPYRIDYLPHOSPHINE LIGAND; MICHAELIS-ARBUZOV REACTION; PHOSPHINE OXIDES; DIAZO-COMPOUNDS; STRUCTURAL-CHARACTERIZATION; PHOSPHORUS PRONUCLEOPHILES; ORGANOPHOSPHORUS COMPOUNDS; MULTICOMPONENT SYNTHESIS; BETA-KETOPHOSPHONATES;

D O I：

10.3390/molecules28062472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterocycles functionalized with pentavalent phosphorus are of great importance since they include a great variety of biologically active compounds and pharmaceuticals, advanced materials, and valuable reactive intermediates for organic synthesis. Significant progress in synthesis of P(O)R-2-substituted six-membered heterocycles has been made in the past decade. This review covers the synthetic strategies towards aromatic monocyclic six-membered N-heterocycles, such as pyridines, pyridazines, pyrimidines, and pyrazines bearing phosphonates and phosphine oxides, which were reported from 2012 to 2022.

引用

页数：31

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