The role of vitamin D in cancer prevention

被引：0

作者：

Rachel A.Ness ^{[1
]}

Duane D.Miller ^{[1
]}

Wei LI ^{[1
]}

机构：

[1] Department of Pharmaceutical Sciences,University of Tennessee Health Sciences Center

来源：

Chinese Journal of Natural Medicines | 2015年 / 13卷 / 07期

关键词：

Vitamin D; Calcitriol; Cancer prevention; Cancer prognosis; Vitamin D deficiency;

D O I：

暂无

中图分类号：

R730.1 [肿瘤的预防与控制];

学科分类号：

100214 ;

摘要：

Vitamin D,also known as cholecalciferol,is the precursor to the active steroid hormone 1,25-dihydroxyvitamin D3(calcitriol; 1,25(OH)2D3).The main physiological role for 1,25(OH)2D3 is to regulate calcium and inorganic phosphate homeostasis for bone health.More recently,vitamin D has been investigated for its effects in the prevention and treatment of a variety of diseases such as cancer,autoimmune disorders,and cardiovascular disease.Preclinical data strongly support a role for vitamin D in the prevention of cancer through its anti-proliferative,pro-apoptotic,and anti-angiogenic effects on cells.Epidemiologic and clinical studies have shown mixed data on the correlation between serum vitamin D levels and cancer risk.This report seeks to outline results from the most recent preclinical and clinical studies investigating the potential role of vitamin D in cancer prevention.

引用

页码：481 / 497

页数：17

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