The role of vitamin D in cancer prevention

被引：0
|
作者：
Rachel A.Ness [1 ]
Duane D.Miller [1 ]
Wei LI [1 ]
机构：
[1] Department of Pharmaceutical Sciences,University of Tennessee Health Sciences Center
来源：
Chinese Journal of Natural Medicines | 2015年 / 13卷 / 07期
关键词：
Vitamin D; Calcitriol; Cancer prevention; Cancer prognosis; Vitamin D deficiency;
D O I：
暂无
中图分类号：
R730.1 [肿瘤的预防与控制];
学科分类号：
100214 ;
摘要：
Vitamin D,also known as cholecalciferol,is the precursor to the active steroid hormone 1,25-dihydroxyvitamin D3(calcitriol; 1,25(OH)2D3).The main physiological role for 1,25(OH)2D3 is to regulate calcium and inorganic phosphate homeostasis for bone health.More recently,vitamin D has been investigated for its effects in the prevention and treatment of a variety of diseases such as cancer,autoimmune disorders,and cardiovascular disease.Preclinical data strongly support a role for vitamin D in the prevention of cancer through its anti-proliferative,pro-apoptotic,and anti-angiogenic effects on cells.Epidemiologic and clinical studies have shown mixed data on the correlation between serum vitamin D levels and cancer risk.This report seeks to outline results from the most recent preclinical and clinical studies investigating the potential role of vitamin D in cancer prevention.
引用
收藏
页码：481 / 497
页数：17
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