Asymmetric hydroazidation of α-substituted vinyl ketones catalyzed by chiral primary amine

被引：0

作者：

Zai-Kun Xue ^{[1
]}

Nian-Kai Fu ^{[1
]}

San-Zhong Luo ^{[1
]}

机构：

[1] Beijing National Laboratory for Molecular Sciences(BNLMS),CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences

来源：

Chinese Chemical Letters | 2017年 / 28卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Chiral primary amine catalysis; Hydroazidation; Enamine protonation; α-Substituted vinyl ketones; Aza-Michael addition; Chiral β-azido ketones;

D O I：

暂无

中图分类号：

O621.251 [];

学科分类号：

摘要：

We report herein the first example of asymmetric hydroazidation of α-substituted vinyl ketones by using chiral primary amines as the catalysts.A simple chiral primary-tertiary diamine catalyst derived from lphenylalanine was found to readily promote this aza-Michael addition reaction with enamine protonation as the key stereogenic step,thus enabling the effective synthesis of α-chiral β-azido ketones with good yields and moderate enantioselectivities.

引用

页码：1083 / 1086

页数：4

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