Asymmetric Retro- and Transfer-Aldol Reactions Catalyzed by a Simple Chiral Primary Amine

被引：49
|
作者：
Luo, Sanzhong [1 ]
Zhou, Pengxin [2 ,3 ]
Li, Jiuyuan [1 ]
Cheng, Jin-Pei [2 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China
[2] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 15期
关键词：
aldol reaction; enantioselectivity; kinetic resolution; organocatalysis; retro reactions; LI HETEROBIMETALLIC COMPLEXES; DIRECT SYN-ALDOL; KINETIC RESOLUTION; KETONES; ORGANOCATALYSTS; ALDEHYDES; DESIGN; ACID; SELECTIVITY; QUATERNARY;
D O I：
10.1002/chem.201000181
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Figure Presented) One stone four birds: A single chiral primary amine was found to catalyze unprecedented asymmetric retro-aldol and transfer-aldol reactions, leading to four different chiral aldol adducts from one common chiral source with up to 99:1 d.r. and 99% ee (see scheme). © 2010 Wiley-VCH Verlag GmbH& Co. KGaA.
引用
收藏
页码：4457 / 4461
页数：5
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