Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system

被引：1
|
作者：
Wei Tiana [1 ]
Bowen Li [1 ,2 ]
Duanshuai Tian [1 ]
Wenjun Tang [1 ,2 ]
机构：
[1] State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences
[2] School of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
来源：
Chinese Chemical Letters | 2022年 / 33卷 / 01期
基金：
中国国家自然科学基金;
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学科分类号：
摘要：
A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4 A molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.
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页码：197 / 200
页数：4
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