Enantioselective Pd-catalyzed allylic alkylation of Indoles by a new class of chiral ferrocenyl P/S Ligands

被引：119

作者：

Cheung, Hong Yee ^{[1
]}

Yu, Wing-Yiu ^{[1
]}

Lam, Fuk Loi ^{[1
]}

Au-Yeung, Terry T. -L. ^{[1
]}

Zhou, Zhongyuan ^{[1
]}

Chan, Tak Hang ^{[1
]}

Chan, Albert S. C. ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synthes, Open Lab Chirotechnol, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 21期

关键词：

D O I：

10.1021/ol7018532

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-Ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.

引用

页码：4295 / 4298

页数：4

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