The Expression of Interleukin-23 (p19/p40) and Inteleukin-12 (p35/p40) in Psoriasis Skin

被引：6
|
作者：
陈旭娥
谭志建
岳青
刘厚君
刘志香
李家文
机构：
[1] Wuhan 430022 China
[2] Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology
[3] Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology
来源：
Current Medical Science | 2006年 / 06期
关键词：
psoriasis; IL-23p19; IL-23/IL-12p40; IL-12; p35;
D O I：
暂无
中图分类号：
R758.63 [牛皮癣（银屑病）];
学科分类号：
100206 ;
摘要：
In order to investigate the mRNA expression and function of interleukin-23 (p19/p40) and interleukin-12 (p35/p40) in the psoriatic lesion, no-lesion and normal human skin, reverse transcrip-tase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-23 (p19/p40) and IL-12 (p35/p40). The results showed that the expression of IL-23p19 mRNA and p40 (IL-12/IL-23) mRNA were higher in psoriatic lesion than those of non-lesional skin and normal skin. The levels of IL-23p19 mRNA and p40 (IL-12/IL-23) mRNA were higher in psoriatic non-lesional skin than nor-mal skin. However, no significant difference was found in the level of IL-12p35 mRNA among the psoriatic lesional skin, non-lesional skin and normal skin. It was suggested that IL-23 might be more important in the pathogenesis of psoriasis than IL-12.
引用
收藏
页码：750 / 752
页数：3
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