A Study on the Expression of Interleukin(IL)-10 and IL-12 P35, P40 mRNA in the Psoriatic Lesions

被引：0

作者：

程纪群

涂亚庭

李家文

黄长征

刘道凡

刘志香

机构：

来源：

Current Medical Science | 2001年 / 01期

关键词：

psoriasis vulgaris; IL; 10; 12; RT PCR;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To investigate the possible role of interleukin (IL) 10 and IL 12 in the pathogenesis of psoriatic lesions and to supply theoretical basis for the gene therapy for psoriasis, the expression of IL 10 and IL 12 P35, P40 mRNA in 12 cases of psoriatic lesions and 6 normal skin tissues was detected by using RT PCR technique. The results showed that the expression of IL 10 mRNA in the psoriatic lesions was significantly lower than that in the normal skin tissues ( P <0.001). The expression of IL 12 P35 was positive both in the psoriatic lesions and in the normal skin tissues. IL 12 P40 mRNA was expressed positively only in the psoriatic lesions but negatively in the normal skin tissues. It was suggested that IL 12 might take an important role in the occurrence and progression of psoriasis, but IL 10 might have certain role in the regression of psoriasis.

引用

页码：86 / 88

页数：3

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