A study on the expression of interleukin (IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions

被引：0
|
作者：
Cheng, J. [1 ]
Tu, Y. [1 ]
Li, J. [1 ]
Huang, C. [1 ]
Liu, Z. [1 ]
Liu, D. [1 ]
机构：
[1] Department of Dermatology, Huazhong Univ. of Sci. and Technol., Xiehe Hospital, Wuhan 430022, China
来源：
Journal of Tongji Medical University | 2001年 / 21卷 / 01期
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摘要：
To investigate the possible role of interleukin (IL)-10 and IL-12 in the pathogenesis of psoriatic lesions and to supply theoretical basis for the gene therapy for psoriasis, the expression of IL-10 and IL-12 P35, P40 mRNA in 12 cases of psoriatic lesions and 6 normal skin tissues was detected by using RT-PCR technique. The results showed that the expression of IL-10 mRNA in the psoriatic lesions was significantly lower than that in the normal skin tissues (P less than or equal 0.001). The expression of IL-12 P35 was positive both in the psoriatic lesions and in the normal skin tissues. IL-12 P40 mRNA was expressed positively only in the psoriatic lesions but negatively in the normal skin tissues. It was suggested that IL-12 might take an important role in the occurrence and progression of psoriasis, but IL-10 might have certain role in the regression of psoriasis.
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页码：86 / 88
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