Diverse strategic approaches en route to Taxol total synthesis

被引：0

作者：

Zexian Li ^{[1
]}

Jianfeng Zheng ^{[1
]}

Wei-Dong Z.Li ^{[1
]}

机构：

[1] Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University

来源：

Chinese Chemical Letters | 2022年 / 33卷 / 12期

基金：

中央高校基本科研业务费专项资金资助; 中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

TQ464.2 [萜类及其衍生物];

学科分类号：

100705 ;

摘要：

Taxol is one of the most famous diterpenoid natural products used in clinical cancer therapy. Taxol and its analogues are popular synthetic targets and have attracted worldwide attention over the past decades.Tremendous research efforts have already been made and ten groups have achieved the total synthesis of Taxol since 1994. This mini-review summarized the recent highlights of divergent strategic approaches towards the chemical synthesis of Taxol’s carbocyclic framework bearing a bridged eight-membered ring.

引用

页码：4957 / 4968

页数：12

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