Benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids:Design,synthesis and in vitro anti-mycobacterial activity evaluation

被引：2
|
作者：
Yaohuan Zhang [1 ]
Ruo Wang [1 ]
Tesen Zhang [1 ]
Weitao Yan [1 ]
Yihong Chen [1 ]
Yanping Zhang [1 ]
机构：
[1] Muyang Zhou College of Chemistry, Fuzhou University
来源：
Chinese Chemical Letters | 2019年 / 30卷 / 03期
关键词：
Benzofuran; Isatin; Hybrid compounds; Anti-mycobacterial; Anti-tubercular; Multi-drug resistant; Structure-activity relationship;
D O I：
暂无
中图分类号：
TQ460.1 [基础理论];
学科分类号：
1007 ;
摘要：
A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H;Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H;Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.
引用
收藏
页码：653 / 655
页数：3
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