Benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids:Design,synthesis and in vitro anti-mycobacterial activity evaluation

被引：2

作者：

Yaohuan Zhang ^{[1
]}

Ruo Wang ^{[1
]}

Tesen Zhang ^{[1
]}

Weitao Yan ^{[1
]}

Yihong Chen ^{[1
]}

Yanping Zhang ^{[1
]}

机构：

[1] Muyang Zhou College of Chemistry, Fuzhou University

来源：

Chinese Chemical Letters | 2019年 / 30卷 / 03期

关键词：

Benzofuran; Isatin; Hybrid compounds; Anti-mycobacterial; Anti-tubercular; Multi-drug resistant; Structure-activity relationship;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H;Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H;Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.

引用

页码：653 / 655

页数：3

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