Design, Synthesis, and In Vitro Anti-Mycobacterial Activities of Tetraethylene Glycol Tethered Isatin Dimers

被引：10
|
作者：
Zhao, Shi-Jia [1 ]
Lv, Zao-Sheng [1 ]
Shi, Lin [2 ]
Zhao, Shuang-Qi [3 ]
Xu, Zhi [4 ]
机构：
[1] Wuhan Univ Sci & Technol, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan, Hubei, Peoples R China
[2] Wuhan Wujing Med Co Ltd, Wuhan, Hubei, Peoples R China
[3] Hubei Engn Univ, Sch Chem & Mat Sci, Xiaogan, Hubei, Peoples R China
[4] Huanghuai Univ, Zhumadian, Henan, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 12期
关键词：
CONTAINING DERIVATIVES; HYBRIDS; CIPROFLOXACIN;
D O I：
10.1002/jhet.3324
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new class of istain dimers tethered by tetraethylene glycol was designed, synthesized, and evaluated for their in vitro anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv and multidrug-resistant M. tuberculosis strains. Our results indicated that all the synthesized hybrids exhibited promising anti-mycobacterial activities against the tested strains and the enriched structure-activity relationship may pave the way to further rational development of istain dimers with a unique mechanism of action different from that of the currently used drugs to overcome the resistance.
引用
收藏
页码：2985 / 2989
页数：5
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