Animal models for filovirus infections

被引：1

作者：

Vinayakumar Siragam ^{[1
,2
]}

Gary Wong ^{[1
,2
,3
,4
]}

Xiang-Guo Qiu ^{[1
,2
]}

机构：

[1] Special Pathogens Program, Public Health Agency of Canada

[2] Department of Medical Microbiology, University of Manitoba

[3] Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital

[4] Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

来源：

Zoological Research | 2018年 / 39卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Filovirus; Ebola virus; Marburg virus; Marburg virus disease; Ebola virus disease; Mouse adapted ebolavirus; Guinea-pig-adapted ebolavirus; Sudan virus; Plaque-forming units;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学]; R511 [病毒传染病];

学科分类号：

摘要：

The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates(NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

引用

页码：15 / 24

页数：10

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