EMERGING OPTIONS IN DEVELOPMENT FOR TREATMENT OF FILOVIRUS INFECTIONS

被引：1
|
作者：
Cardile, A. P. [1 ]
Mayers, D. L. [2 ]
Bavari, S. [3 ]
机构：
[1] US Army Med Res, Inst Infect Dis, Div Med, Frederick, MD 21702 USA
[2] US Army Med Res, Inst Infect Dis, Therapeut Dev Ctr, Frederick, MD 21702 USA
[3] US Army Med Res, Inst Infect Dis, Frederick, MD 21702 USA
来源：
DRUGS OF THE FUTURE | 2015年 / 40卷 / 11期
关键词：
Ebola; Marburg; BCX-4433; Brincidofovir; Favipiravir; Small-interfering RNAs; Antisense phosphorodiamidate; Morpholino oligomers; Interferon; FX-06; zMapp; Recombinant nematode anticoagulant protein c2; Convalescent plasma; Amodiaquine; EBOLA-VIRUS DISEASE; MARBURG VIRUS; NONHUMAN-PRIMATES; RNA INTERFERENCE; CONVALESCENT PLASMA; HEMORRHAGIC-FEVER; FAVIPIRAVIR T-705; POSTEXPOSURE PROTECTION; NUCLEOSIDE ANALOG; YELLOW-FEVER;
D O I：
10.1358/dof.2015.040.11.2387219
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
As a result of the ongoing Ebola outbreak in West Africa, there have been significant developments in therapeutics against Filovirus over the past year. Not only have novel therapeutics been advanced, but a number of already-approved drugs have demonstrated activity against Ebola virus. This review article summarizes the most important therapeutic agents for both Ebola and Marburg virus. Among the therapeutics discussed, small-molecule inhibitors, nucleic acid-based therapeutics, immune-therapeutics (zMapp, convalescent plasma) and repurposed drugs are all included.
引用
收藏
页码：727 / 738
页数：12
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