Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk

被引：0
|
作者：
Mansour S Al-Moundhri [1 ]
Manal Al-Khanbashi [2 ]
Mohammed Al-Kindi [3 ]
Maryam Al-Nabhani [2 ]
Ikram A Burney [1 ]
Abdulaziz Al-Farsi [4 ]
Bassim Al-Bahrani [4 ]
机构：
[1] Medical Oncology Unit,Department of Medicine,College of Medicine and Health Sciences,Sultan Qaboos University
[2] Department of Clinical Genetics,College of Medicine and Health Sciences,Sultan Qaboos University
[3] Department of Biochemistry,College of Medicine and Health Sciences,Sultan Qaboos University
[4] National Oncology Center,Royal Hospital
来源：
World Journal of Gastroenterology | 2010年 / 16卷 / 27期
关键词：
Gastric cancer; Polymorphism; CDH1;
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.
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收藏
页码：3432 / 3436
页数：5
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