Purinergic Signaling in the Central Nervous System in Health and Disease

被引：0

作者：

Peter Illes ^{[1
,2
]}

Guang-Yin Xu ^{[3
]}

Yong Tang ^{[1
,4
]}

机构：

[1] International Collaborative Centre on Big Science Plan for Purine Signaling,Chengdu University of Traditional Chinese Medicine

[2] Rudolf-Boehm-Institut für Pharmakologie und Toxikologie,Universitaet Leipzig

[3] Institute of Neuroscience,Soochow University

[4] Acupuncture and Chronobiology Key Laboratory of Sichuan Province

来源：

Neuroscience Bulletin | 2020年 / 36卷 / 11期

基金：

国家重点研发计划;

关键词：

D O I：

暂无

中图分类号：

R338 [神经生理学];

学科分类号：

0710 ; 071006 ;

摘要：

The existence of purinergic signaling—the idea that almost all cells of the animal/human organism are able to communicate with each other via extracellular purines—was proposed by Geoffrey Burnstock (1929-2020) in 1972[1-3].The purinergic system includes the following constituents:(1) the four main purines:adenosine triphosphate (ATP) and its metabolites,adenosine diphosphate(ADP),adenosine monophosphate (AMP),and adenosine(ADO);(2) three key enzymes,the ectonucleoside triphosphate diphosphohydrolases (E-NTPDases:NTPDase1/CD39),ectonucleotide pyrophosphatase/phosphodiesterases (E-NPP),and ecto-5’-nucleotidase (E-5’-nucleotidase/CD73),which decompose ATP into ADP,AMP,and ADO;and (3) nineteen purinergic receptors:four subtypes of G protein-coupled P1 receptors (A1, A2A, A2B, and

引用

页码：1239 / 1241

页数：3

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