Purinergic Signaling in the Central Nervous System in Health and Disease

被引：0
|
作者：
Peter Illes [1 ,2 ]
Guang-Yin Xu [3 ]
Yong Tang [1 ,4 ]
机构：
[1] International Collaborative Centre on Big Science Plan for Purine Signaling,Chengdu University of Traditional Chinese Medicine
[2] Rudolf-Boehm-Institut für Pharmakologie und Toxikologie,Universitaet Leipzig
[3] Institute of Neuroscience,Soochow University
[4] Acupuncture and Chronobiology Key Laboratory of Sichuan Province
来源：
Neuroscience Bulletin | 2020年 / 36卷 / 11期
基金：
国家重点研发计划;
关键词：
D O I：
暂无
中图分类号：
R338 [神经生理学];
学科分类号：
0710 ; 071006 ;
摘要：
The existence of purinergic signaling—the idea that almost all cells of the animal/human organism are able to communicate with each other via extracellular purines—was proposed by Geoffrey Burnstock (1929-2020) in 1972[1-3].The purinergic system includes the following constituents:(1) the four main purines:adenosine triphosphate (ATP) and its metabolites,adenosine diphosphate(ADP),adenosine monophosphate (AMP),and adenosine(ADO);(2) three key enzymes,the ectonucleoside triphosphate diphosphohydrolases (E-NTPDases:NTPDase1/CD39),ectonucleotide pyrophosphatase/phosphodiesterases (E-NPP),and ecto-5’-nucleotidase (E-5’-nucleotidase/CD73),which decompose ATP into ADP,AMP,and ADO;and (3) nineteen purinergic receptors:four subtypes of G protein-coupled P1 receptors (A1, A2A, A2B, and
引用
收藏
页码：1239 / 1241
页数：3
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