Copper-catalyzed N-arylation of 2-arylindoles with aryl halides

被引：1
|
作者：
Wei Liu [1 ]
Li-Ya Han [1 ]
Rui-Li Liu [1 ]
Li-Ge Xu [1 ]
Yan-Lan Bi [1 ]
机构：
[1] College of Food Science and Technology,Henan University of Technology
来源：
Chinese Chemical Letters | 2014年 / 25卷 / 09期
基金：
中国国家自然科学基金;
关键词：
2-Arylindoles; Aryl halides; N-Arylation; Copper;
D O I：
暂无
中图分类号：
O621.251 [];
学科分类号：
070303 ; 081704 ;
摘要：
10 mol% CuI combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields.The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.
引用
收藏
页码：1240 / 1243
页数：4
相关论文
共 50 条
  • [1] Copper-catalyzed N-arylation of 2-arylindoles with aryl halides
    Liu, Wei
    Han, Li-Ya
    Liu, Rui-Li
    Xu, Li-Ge
    Bi, Yan-Lan
    [J]. CHINESE CHEMICAL LETTERS, 2014, 25 (09) : 1240 - 1243
  • [2] Mild copper-catalyzed N-arylation of azaheterocycles with aryl halides
    Kuil, M
    Bekedam, EK
    Visser, GM
    van den Hoogenband, A
    Terpstra, JW
    Kamer, PCJ
    van Leeuwen, PWNM
    van Strijdonck, GPF
    [J]. TETRAHEDRON LETTERS, 2005, 46 (14) : 2405 - 2409
  • [3] Copper-catalyzed N-Arylation of Imidazoles with Aryl or Heteroaryl Halides Facilitated by Dimethylglyoxime in Water
    Wu Xiangmei
    Hu Weiya
    [J]. CHINESE JOURNAL OF CHEMISTRY, 2011, 29 (10) : 2124 - 2128
  • [4] Copper-Catalyzed N-Arylation of 2-Imidazolines with Aryl Iodides
    Davis, Owen A.
    Hughes, Matthew
    Bull, James A.
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (07): : 3470 - 3475
  • [5] Commercial drug norfloxacin as a novel ligand for the copper-catalyzed N-arylation of imidazole with aryl halides
    Wu, Fengtian
    Nan, Chenlong
    Ma, Minyang
    Li, Huiqin
    Xie, Jianwei
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (11)
  • [6] Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides
    Yin, Huiqing
    Jin, Ming
    Chen, Wei
    Chen, Chen
    Zheng, Likang
    Wei, Ping
    Han, Shiqing
    [J]. TETRAHEDRON LETTERS, 2012, 53 (10) : 1265 - 1270
  • [7] Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water
    Yong, Fui-Fong
    Teo, Yong-Chua
    Chua, Guan-Leong
    Lim, Gina Shiyun
    Lin, Yizhen
    [J]. TETRAHEDRON LETTERS, 2011, 52 (11) : 1169 - 1172
  • [8] Deciphering the mechanism of copper-catalyzed N-arylation between aryl halides and nitriles: a DFT study
    Ahmad, Khalil
    Khan, Bilal Ahmad
    Akhtar, Tashfeen
    Khan, Jahanzeb
    Roy, Soumendra K.
    [J]. NEW JOURNAL OF CHEMISTRY, 2019, 43 (48) : 19200 - 19207
  • [9] The copper-catalyzed N-arylation of indoles
    Antilla, JC
    Klapars, A
    Buchwald, SL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (39) : 11684 - 11688
  • [10] Copper-Catalyzed N-Arylation of Sulfonimidamides
    Azzaro, Stephane
    Desage-El Murr, Marine
    Fensterbank, Louis
    Lacote, Emmanuel
    Malacria, Max
    [J]. SYNLETT, 2011, (06) : 849 - 851
12345