Effects of Dachengqi Decoctions Made from Different Processed Products of Rhubarb on ABP Mice

[Objectives] This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake, defecation amount, urination amount, urination volume, dryness of stool, mental state and activity of ABP mice. [Methods] Total 165 mice were randomly divided into Dachengqi decoction groups(made from different processed products of rhubarb, 6 and 10 g/kg), positive control group, blank control group and model group. The administration dosage was 20 mL/kg. With the metabolic cage integral method, the effects of Dachengqi decoctions made from different processed products of rhubarb on the water intake, defecation amount, urination volume, dryness of stool, mental state and activity of ABP mice were compared. [Results] Dachengqi decoctions all could soften stool and promote rapid defecation of the mice with fecal peritonitis of excess heat stagnation type except that made from carbonized rhubarb. The water intakes of all the Dachengqi decoction groups were higher than those of the positive control group and the model group, except the carbonized rhubarb-made Dachengqi decoction groups. [Conclusions] Dachengqi decoctions all have obvious purgative effect except those made from carbonized rhubarb.