Synthesis and Antitumor Activity of Podophyllotoxin Analogues

被引：0

作者：

鲁宽科

刘方明

陈耀祖

机构：

[1] 兰州大学应用有机国家重点实验室

[2] 北京医科大学药学院应用药物研究所

来源：

JournalofChinesePharmaceuticalSciences | 1998年 / 04期

关键词：

鬼臼毒素; 抗肿瘤活性; 1.2.4-三唑;

D O I：

暂无

中图分类号：

R914.5 [有机合成药物化学];

学科分类号：

摘要：

在三氟乙酸催化下，由４′去甲基表鬼臼毒素１０和５烷基４氨基３巯基１，２，４三唑９（ａｇ）合成了７个目标化合物１１（ａｇ），并对它们进行了ＨＬ６０、Ｋ５６２细胞株体外活性试验，结果表明：１１（ａｇ）对Ｋ５６２细胞株显示出较强的活性。

引用

页码：15 / 18

页数：4

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