Reverse spillover of SARS-CoV-2 from human to wild animals

The heavily transmitted and mutated SARS-CoV-2 has constitutes a sustained threat to global health. A recent article published in Nature, firstly provided solid evidence confirming the cross-species transmission of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) from human to free-ranging white-tailed deer(Hale et al., 2022).More importantly, circulation of SARS-CoV-2 among deer rapidly resulted into new phylogenetic clades of deer-only viruses which were believed linking to the high infection rate of SARS-CoV-2 within white-tailed deer in northeast Ohio,USA(Hale et al., 2022).